- Ball Family Papers, 1631-1895206
- Berkeley County (S.C) Memories1
- Berkeley County (S.C.) Memories4
- Beulah Glover Photograph Collection5
- Books and Pamphlets1
- Bowman Family Papers, 1835-18923
- Buildings and Properties, 1841-193749
- Burton L. Padoll Papers, 1957-2009110
- Butler Derrick: In His Own Words2
- C. Wayne Weart Apothecary Trade Cards, 1870-1920251
- C. Wayne Weart Pharmacy History Collection37
- Catherine M. McCottry, M.D. Papers12
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser's Sketchbook, 1796-1805114
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,401
- Charles Stuart Vedder Papers3
- Charleston Bible Society Records, 1815-20101
- Charleston City Directories4
- Charleston City Records Collection1
- Charleston Dental Association Records30