- City Year Books for Charleston, South Carolina, 1880-19517
- Rabbi Jacob S. Raisin Papers5
- Richard Furman and James C. Furman Collection5
- Works Progress Administration photograph collection: South Carolina places : 193u-194u.5
- Charleston Dental Association Records4
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)4
- Edmondston-Alston Family Letters and Paper Materials, 1782-19194
- Waring Historical Library Artifact Collection4
- Aqui Estamos3
- Illustrated Newspaper Clippings, 1840-19173
- Medical University of South Carolina Board of Trustees Collection, 1824-20123
- Septima P. Clark Papers, ca. 1910-ca. 19903
- WPA Federal Writers' Project on African American Life in South Carolina3
- William Ancrum Letter Book and Account Book3
- Isaiah DeQuincey Newman Papers2
- James Simons Papers, 1832-18792
- MUSC Anatomy Class and Dissection Room Photographs2
- MUSC College of Pharmacy Class Photos2
- Malloy Family Papers, 1861-19072
- Middleton Papers, 1775-18152