- Medical University of South Carolina Board of Trustees Collection, 1824-201271
- Aqui Estamos70
- Waring Historical Library Medical Caricatures68
- Philip Simmons Collection63
- City Year Books for Charleston, South Carolina, 1880-195162
- Town of Sullivan's Island Historic Meeting Minutes62
- Grimke family papers, 1678-197760
- Stereographic Views of South Carolina60
- Cloe T.W. Greene Diaries59
- Langdon Cheves Papers, 1777-186456
- Hampstead and Bethany Cemeteries53
- MUSC College of Medicine Class Photos53
- Thomas Pinckney papers, ca. 1790-ca. 1825.52
- South Carolina LGBTQ Oral Histories, Archives, and Outreach51
- Buildings and Properties, 1841-193749
- Agricultural Society of South Carolina Visual Materials47
- College of Charleston Magazines47
- Ansonborough Rehabilitation Project46
- Oliver Hart papers, 1741-196142
- Isaiah DeQuincey Newman Papers39