- South Carolina LGBTQ Oral Histories, Archives, and Outreach50
- Buildings and Properties, 1841-193749
- Agricultural Society of South Carolina Visual Materials47
- College of Charleston Magazines47
- Ansonborough Rehabilitation Project46
- City of Charleston Board of Architectural Review Photographs Collection43
- Oliver Hart papers, 1741-196142
- Isaiah DeQuincey Newman Papers39
- C. Wayne Weart Pharmacy History Collection37
- Ethelyn Murray Parker Papers35
- Charleston Dental Association Records30
- Henrietta Yurchenco Field Recordings, 1970-197129
- Historic Charleston Foundation Oral History Project28
- Thomas J. Tobias papers, ca. 1790-197028
- Illustrated Newspaper Clippings, 1840-191727
- John McCrady Plats and Deeds Collection27
- Laura Bragg Papers27
- Drayton Papers, 1701-200426
- Edmondston-Alston Family Letters and Paper Materials, 1782-191926
- Phosphates in South Carolina, 1870-189026