- Deas Family Papers and Research, 1766-19762
- Elizabeth W. Allston Pringle Family Papers, 1861-19262
- Hasell Family Papers, 1803 - 18842
- James T. McCain Papers, 1957-19722
- Jewish Heritage Collection Oral Histories2
- Jimmy Price Studios2
- Langdon Cheves Papers, 1777-18642
- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-19202
- Postcard Collection of Mullins, South Carolina2
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library2
- South Carolina State Parks Civilian Conservation Corps Architectural Plans2
- Weston Family Papers, 1764-18552
- AccessAble Books1
- Alexander Glennie Journal, 1831-18591
- Alice Ravenel Huger Smith Collection1
- Atlas of the state of South Carolina by Robert Mills1
- Charlotte Kaminski Scrapbook Collection1
- Clemson University Board of Trustees Minutes and Reports1
- Dirleton Plantation Memorandum Book, 1859-19281
- Early California Scrapbooks1