- Jewish Heritage Collection Oral Histories1
- Jimmy Price Studios1
- John Henry McCray papers, 1929-19893
- MUSC Anatomy Class and Dissection Room Photographs1
- MUSC College of Medicine Class Photos2
- MUSC College of Pharmacy Class Photos1
- Pawleys Island Civic Association1
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library2
- Richard Furman and James C. Furman Collection1
- Senator Burnet R. Maybank Papers, 1914-19731
- Septima P. Clark Papers, ca. 1910-ca. 19901
- Sheet music from the Joseph M. Bruccoli Great War Collection2
- South Carolina Fall Line Collection1
- South Carolina Historical Records Survey Collection4
- South Carolina LGBTQ Oral Histories, Archives, and Outreach4
- South Carolina Postcards6
- South Carolina State Parks Signs, Brochures, and Manuals18
- South Carolina and the Spanish American War2
- Strom Thurmond Collection, Mss 1002
- Tarbox Collection1