- John Henry McCray papers, 1929-19898
- William D. Workman, Jr. Papers Photographs8
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19957
- Grimke family papers, 1678-19777
- M. Hayes Mizell Papers7
- South Carolina LGBTQ Oral Histories, Archives, and Outreach7
- Stereographic Views of South Carolina7
- Women's education in early 20th century Greenville7
- George LaGrange Cook Photograph Collection6
- Harvey Gantt and the Integration of Clemson University6
- History of the University of South Carolina School of Medicine - Columbia6
- President Robert C. Edwards Papers6
- Thomas Benton Brooks Papers6
- C. Wayne Weart Apothecary Trade Cards, 1870-19205
- Cleveland L. Sellers, Jr. Papers, 1934 - 20035
- Georgetown County Digital Library5
- MUSC College of Medicine Class Photos5
- William A. Rosenthall Judaica Collection - Prints and Photographs5
- World War I, Irvin Department of Rare Books and Special Collections5
- Greenwood Mills Photograph Collection4