- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)10
- Isaac Rosenberg: Early Poetry and Related Documents from the Joseph Cohen Collection of World War I Literature10
- Colin J. McRae Papers, Huse Audit Series9
- Lawrence Layden Scrapbook, 1941-19459
- The Development of the Printed Page: 150 Examples of Handpress Printing and its Antecedents, ca. 1200 to 19379
- Edmondston-Alston Family Letters and Paper Materials, 1782-19198
- Georgetown County World War II Memories8
- Gabriel Manigault Journal, 1774-17847
- James Glen Papers7
- Augusta Baker Papers, 1911-19986
- Belle W. Baruch Collection5
- Jewish Heritage Collection Oral Histories5
- William Lynch Postcard Collection5
- Grimke family papers, 1678-19774
- Halley's Comet Project, 1985-19864
- Harvey Gantt and the Integration of Clemson University4
- John Shaw Billings Scrapbook4
- John and Mary Osman Braun and Hogenberg Collection4
- Library of English Literature4
- Loretta Dunbar oral correspondence collection, 1974-19794