- Isaiah DeQuincey Newman Papers3
- Robert McNair: In His Own Words3
- Smith and Wells Papers, 1856-19073
- Strom Thurmond Collection, Mss 1003
- The Charleston Oral History Program3
- Voice of an Island Oral Histories and Service Recordings, 2012-20133
- Bernice Robinson Papers, 1920-19892
- Eric Crawford Spiritual Recordings, 2007-20102
- Eugene C. Hunt Papers, 1834 - 19942
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections2
- Lanny and Sidney Palmer Collection2
- Medical University of South Carolina Board of Trustees Collection, 1824-20122
- Septima P. Clark Papers, ca. 1910-ca. 19902
- Upstate African American Genealogy2
- Upstate African American Genealogy
2
- William ("Bill") Saunders Papers, circa 1950 - 20042
- William A. Rosenthall Judaica Collection - Postcards2
- William A. Rosenthall Judaica Collection - Prints and Photographs2
- Adger Family Papers, 1813-19321
- Allston Family Papers, 1730-19011