- Smith and Wells Papers, 1856-19073
- Bacot Family Papers, 1752-19732
- Brookgreen Gardens Collection2
- Eleanor Parsons Moody Collection2
- Eugene C. Hunt Papers, 1834 - 19942
- John Henry McCray papers, 1929-19892
- John Shaw Billings Scrapbook2
- Papers of the Cox and Chesnut Families, 1792-18582
- Septima P. Clark Papers, ca. 1910-ca. 19902
- Temple Sinai (Sumter, S.C.) Records2
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera2
- William A. Rosenthall Judaica Collection - Postcards2
- William D. Workman, Jr. Papers Photographs2
- William Gravely Oral History Collection on the Lynching of Willie Earle2
- Alexander Glennie Journal, 1831-18591
- Ball Family Papers, 1631-18951
- Bernice Robinson Papers, 1920-19891
- Buildings and Properties, 1841-19371
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19951
- Civil Rights Films from Moving Image Research Collections1