- Civil Rights Films from Moving Image Research Collections6
- Henry William Ravenel, Plants and Planter6
- John Henry McCray papers, 1929-19895
- Augusta Baker Papers, 1911-19984
- Senator Burnet R. Maybank Papers, 1914-19734
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera4
- White Pines Series of Architectural Monographs Collection4
- Williams Furniture Company Collection4
- YWCA of Greater Charleston, Inc., Records, 1906 - 20074
- Butler Derrick: In His Own Words3
- Edwin Hughes Collection3
- Pawleys Island Civic Association3
- Robert McNair: In His Own Words3
- Sheet music from the Joseph M. Bruccoli Great War Collection3
- South Carolina and World War II3
- Strom Thurmond Collection, Mss 1003
- Due West Female College Photograph Collection2
- From the Kitchen Drawer and Cupboard: The Jerred Metz Collection of Manufacturers' Recipe and Advertisement Booklets 1902-19502
- Harbison Agricultural College Photograph Collection2
- Henry William Ravenel Papers, 1739-19352