- South Carolina and the Civil War17
- YWCA of Greater Charleston, Inc., Records, 1906 - 200716
- Russell Maxey Photograph Collection15
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections14
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library14
- Columbia Theater and Entertainment13
- Joseph A. DeLaine Papers13
- Lonnie W. Fleming, Sr. Photograph Collection13
- Septima P. Clark Papers, ca. 1910-ca. 199013
- South Carolina LGBTQ Oral Histories, Archives, and Outreach13
- William Drayton Rutherford Papers13
- At Low Tide Photographs12
- Harry and William Birch Collection12
- Local Television Newsfilm Collections12
- L.A. Hall Civil War and Reconstruction Eras Stereoscopic Images11
- Papers of the Cox and Chesnut Families, 1792-185811
- William A. Rosenthall Judaica Collection - Prints and Photographs10
- George LaGrange Cook Photograph Collection9
- Harvey Gantt and the Integration of Clemson University9
- Henrietta Yurchenco Field Recordings, 1970-19719