- Harry and William Birch Collection3
- Rabbi Jacob S. Raisin Papers3
- Smith and Wells Papers, 1856-19073
- South Carolina Historical Records Survey Collection3
- The Charleston Oral History Program3
- Topographical Maps of South Carolina, 1888 -19753
- United States Marine Corps Films3
- Bicentennial Photograph Collection2
- Harvey Gantt and the Integration of Clemson University2
- Henry Laurens papers, 1747-18602
- Henry William Ravenel, Plants and Planter2
- John Henry McCray papers, 1929-19892
- Malloy Family Papers, 1861-19072
- President Robert C. Edwards Papers2
- Russell Maxey Photograph Collection2
- Sheet music from the Joseph M. Bruccoli Great War Collection2
- The WPA Week in National Defense2
- Tom Crosby oral history collection, 2006-20112
- William Drayton Rutherford Papers2
- Williams, Chesnut, Manning Family Papers, 1682-19262