- Political Campaign Memorabilia Collection30
- South Carolina State Parks Signs, Brochures, and Manuals28
- Camilla Urso Collection26
- James T. McCain Papers, 1957-197226
- South Caroliniana Pamphlet Collection25
- Aqui Estamos19
- Richard Furman and James C. Furman Collection18
- Phillis Wheatley Community Center17
- South Carolina Public Library History, 1930 - 194517
- The WPA Week in National Defense17
- YWCA of Greater Charleston, Inc., Records, 1906 - 200716
- Bonds Conway Papers, 1763-190714
- Phosphates in South Carolina, 1870-189014
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera14
- United States Food Administration Food Conservation Notes13
- Esau Jenkins Papers, 1963-200311
- M. Hayes Mizell Papers11
- Williams Furniture Company Collection11
- From the Kitchen Drawer and Cupboard: The Jerred Metz Collection of Manufacturers' Recipe and Advertisement Booklets 1902-195010
- John Shaw Billings Scrapbook9