- John Shaw Billings Scrapbook1,371
- South Carolina State Parks Civilian Conservation Corps Architectural Plans1,362
- The Furman Paladin1,292
- Septima P. Clark Papers, ca. 1910-ca. 19901,227
- Georgetown County Historical Survey1,216
- Sheet music from the Joseph M. Bruccoli Great War Collection1,206
- William Lynch Postcard Collection1,204
- The Furman Hornet1,198
- South Carolina Historical Records Survey Collection1,176
- Strom Thurmond Collection, Mss 1001,156
- Bernice Robinson Papers, 1920-19891,130
- Harry and William Birch Collection1,098
- Works Progress Administration photograph collection: South Carolina places : 193u-194u.1,069
- Photos from the Records of The Historic Preservation Planner, BCD-COG985
- South Caroliniana Library Map Collection942
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library940
- Thomas Benton Brooks Papers932
- Greenwood Mills Photograph Collection919
- Postcards of the Midlands913
- Gordon R. Hennigar Pathology Museum Collection900