- South Carolina Veterans Oral History Collection1
- Spartanburg City Directories1
- Springfield Plantation Journal,1831 - 18641
- Stereoscopic Photographs1
- Stoney Family Papers, 1775-19491
- Temple Sinai (Sumter, S.C.) Records1
- Tempo Magazine1
- The Barbara Brown Collection1
- The Fundamental Constitutions of Carolina, 16691
- The Helen Wall Burns Collection1
- Trowbridge Family Papers1
- U.S. Engineer Maps of the Waccamaw River, 19031
- USC Union Programs and Invitations1
- University of South Carolina Aiken Photograph Collection, 1961-20111
- University of South Carolina Football Programs1
- Vanderhorst Family Papers, 1689-19421
- Waring Historical Library Medical Caricatures1
- William Henry Jackson Photochrom Collection, 1898-19051
- Williams, Chesnut, Manning Family Papers, 1682-19331
- Winns of Fairfield County1