- City Engineers's Plat Book, 1671-19511
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)1
- George LaGrange Cook Photograph Collection1
- Georgetown County Digital Library1
- Georgetown County Historical Survey1
- Georgetown County Museum Collection1
- Historic Southern Naturalists1
- J. Arthur Brown Papers, 1937 - 19881
- James Glen Papers1
- Joseph A. DeLaine Papers1
- L. Mendel Rivers Papers, 1940-19621
- L.A. Hall Civil War and Reconstruction Eras Stereoscopic Images1
- MUSC College of Pharmacy Class Photos1
- Mamie E. Garvin Fields Papers, 1894 - 19871
- Manigault Family Papers, 1685-19711
- Middleton Family Art Work, 1803-18671
- Middleton Family Papers, 1736-19291
- Postcards of the Midlands1
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library1
- South Carolina Historical Society Manuscripts1