- Minutes of the Annual Conferences of the Baptist, Episcopal, Lutheran, Methodist, and Presbyterian Churches in South Carolina, 1785-192015
- Gertrude Sanford Legendre Papers, 1844-199614
- Henry William Ravenel Papers, 1739-193514
- South Carolina Railroad Photograph Collection14
- South Carolina LGBTQ Oral Histories, Archives, and Outreach13
- Gas Attack Magazine Collection12
- Topographical Maps of South Carolina, 1888 -197512
- Georgetown County Digital Library11
- Joseph M. Bruccoli Great War Collection: Postcards11
- Richard Furman and James C. Furman Collection11
- South Carolina Library Buildings Collection11
- Ball Family Papers, 1631-189510
- Grimke family papers, 1678-197710
- Irish Heritage Oral History Collection10
- John Henry McCray papers, 1929-198910
- Rabbi Jacob S. Raisin Papers10
- Russell Maxey Photograph Collection10
- Smith and Wells Papers, 1856-190710
- A. Wolfe Davidson Photographs9
- Columbia Theater and Entertainment9