- Augusta Baker Papers, 1911-19982
- Charleston Earthquake 18862
- Fairfield County Manuscript Collection2
- From the Kitchen Drawer and Cupboard: The Jerred Metz Collection of Manufacturers' Recipe and Advertisement Booklets 1902-19502
- Gabriel Manigault Journal, 1774-17842
- Hunger in America2
- Isaiah DeQuincey Newman Papers2
- John Shaw Billings Scrapbook2
- Paul Cross Papers, 1768-18032
- Phosphate, Farms, & Family: The Donner Collection2
- Proclamations, Politics, and Commerce: Broadsides from the Colonial Era to the Present at the South Caroliniana Library2
- Shadows of the Gullah Geechee2
- Sheet music from the Joseph M. Bruccoli Great War Collection2
- Slave Records in the Discrete Manuscript Collection2
- South Carolina LGBTQ Oral Histories, Archives, and Outreach2
- Spartanburg County in World War I Collection2
- St. Andrew's Society of Charleston Records, 1729-20012
- Stereoscopic Photographs2
- Sullivan's Island Oral History Collection2
- The Lucille Hasell Culp Collection2