- Hunger in America21
- Midlands Memories21
- President Robert C. Edwards Papers21
- John Henry McCray papers, 1929-198920
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)19
- Henry William Ravenel, Plants and Planter19
- Medical University of South Carolina Board of Trustees Collection, 1824-201219
- Edmondston-Alston Family Letters and Paper Materials, 1782-191918
- Family Bible Records18
- Herald-Journal Willis Collection18
- Historic Meeting Minutes of Mullins, South Carolina17
- James L. Michie Archaeology Reports17
- Native American South Carolina Digital Archive17
- Russell Maxey Photograph Collection17
- Ariail-Kimball Genealogy16
- Grimke family papers, 1678-197716
- University of South Carolina Buildings and Grounds16
- Papers of the Cox and Chesnut Families, 1792-185815
- William Savage oral history collection, 1982-198815
- Cranston Family Papers, 1822-195914