- Henry William Ravenel, Plants and Planter5
- Lanny and Sidney Palmer Collection5
- M. Hayes Mizell Papers5
- Richland Library Archives5
- Slave Records in the Discrete Manuscript Collection5
- William ("Bill") Saunders Papers, circa 1950 - 20045
- William Ancrum Letter Book and Account Book5
- YWCA of Greater Charleston, Inc., Records, 1906 - 20075
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)4
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)4
- Francis Peyre Porcher Papers4
- George LaGrange Cook Photograph Collection4
- Georgetown County Museum4
- Greenwood County Library Photographs4
- Henry Laurens papers, 1747-18604
- Herald-Journal Willis Collection4
- Historic Meeting Minutes of Mullins, South Carolina4
- Horace Gilbert Smithy, Jr., M.D. Papers4
- J. Marion Sims Letters4
- John Shaw Billings Scrapbook4