- Hutson Lee Papers, 1858-18651
- Isaiah DeQuincey Newman Papers1
- James Calvin Hemphill, Sr. Architectural Collection1
- John A. Silver Penn Spiritual Recordings, 19421
- Kaminski-Prevost Collection1
- Leo S. Carty Watercolor Print Collection1
- Local Television Newsfilm Collections1
- Loretta Dunbar oral correspondence collection, 1974-19791
- M. Hayes Mizell Papers1
- Malloy Family Papers, 1861-19071
- Mathurin Guerin Gibbs Plantation Register, 1824-18751
- Midlands Memories1
- Paul Cross Papers, 1768-18031
- Primary Sources for K-12, Pilot Project1
- Pringle-Garden Family Papers, 1701-18821
- Rose Hill Plantation Time Books, 18781
- Russell Maxey Photograph Collection1
- Slave Records in the Discrete Manuscript Collection1
- South Carolina Historical Records Survey Collection1
- South Carolina Hospital Postcards1