- Langdon Cheves Papers, 1777-186417
- MUSC College of Medicine Class Photos17
- William D. Workman, Jr. Papers Photographs17
- 2nd South Carolina Regiment Paybook, 177516
- Allston Family Papers, 1730-190116
- Buildings and Properties, 1841-193716
- Civil Rights Films from Moving Image Research Collections16
- Colin J. McRae Papers, Huse Audit Series16
- Gooch Family Papers, 1754-194716
- Mills Family of Greenville16
- Stokes Grocery Store Ledger16
- WPA Federal Writers' Project on African American Life in South Carolina16
- Aqui Estamos15
- Carl Julien Collection15
- Edwin Hughes Collection15
- Harry and William Birch Collection15
- Jewish Heritage Collection Oral Histories15
- Maxcy Gregg Papers, 1835-1888.15
- The Development of the Printed Page: 150 Examples of Handpress Printing and its Antecedents, ca. 1200 to 193715
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections14