- Historical and Governing Records, 1841-192510
- Hutson Lee Papers, 1858-186515
- Illustrated Newspaper Clippings, 1840-19173
- Kahal Kadosh Beth Elohim Congregation Records4
- L. Mendel Rivers Papers, 1940-19626
- Levi L. Kibler Letters Received1
- Mamie E. Garvin Fields Papers, 1894 - 198736
- Medical University of South Carolina University Bulletins, 1878-2002182
- Middleton Papers, 1775-18154
- Parish Records1
- Philip Simmons Collection7
- Phillips Family Papers2
- Phillis Wheatley Literary and Social Club Papers4
- Rabbi Jacob S. Raisin Papers63
- Senator Burnet R. Maybank Papers, 1914-197313
- Septima P. Clark Papers, ca. 1910-ca. 1990165
- Temple Sinai (Sumter, S.C.) Records103
- This is Charleston820
- Thomas J. Tobias papers, ca. 1790-197017
- Town of Sullivan's Island Historic Meeting Minutes51