- City Year Books for Charleston, South Carolina, 1880-195126
- City of Charleston Collection1
- Civic Services Committee Papers5
- Clemson Commencement Program1
- Clemson University Board of Trustees Minutes and Reports622
- Clemson University Department of Languages Newsletter41
- Clemson University Faculty Manuals38
- Clemson University Historical Images2
- Cleveland L. Sellers, Jr. Papers, 1934 - 2003715
- Cohen, Emanuel, Moses, Seixas Family Papers4
- Colleton County Memorial Library Bookmobile History2
- Cooperative Annual Reports292
- Early History of Columbia College97
- Erastus W. Everson Papers, 1837-18933
- Esau Jenkins Papers, 1963-2003143
- Ethelyn Murray Parker Papers34
- Eugene C. Hunt Papers, 1834 - 199486
- Fox Movietone News: The War Years204
- Francis Peyre Porcher Papers1
- Frederick E. Kredel, M.D. Papers, 1925-19801