- Henry Orion Nichols Collection 110
- Photograph Survey of the “Charleston Center” Site108
- Georgetown County Digital Library105
- College of Charleston Buildings and Grounds Photograph Collection95
- Native American South Carolina Digital Archive92
- Richland Library Archives90
- Berkeley County (S.C.) Memories84
- Horace Gilbert Smithy, Jr., M.D. Papers83
- Bookmobiles75
- YWCA of Greater Charleston, Inc., Records, 1906 - 200773
- Fort Jackson Library Collection65
- Berkeley County Photograph Collection64
- Anna D. Kelly Papers, 1930s - 199960
- Union Bleachery54
- Camp Sevier51
- Piedmont Manufacturing51
- From the Kitchen Drawer and Cupboard: The Jerred Metz Collection of Manufacturers' Recipe and Advertisement Booklets 1902-195050
- Harby, Moise, Levy, Moses, Davis Family Photographs49
- Pelzer Mill49
- City of Charleston Board of Architectural Review Photographs Collection47