- C. Wayne Weart Apothecary Trade Cards, 1870-1920301
- C. Wayne Weart Pharmacy History Collection32
- Caines Family Photograph Collection40
- Camilla Urso Collection13
- Camp Sevier56
- Camp St. Mary Records, 1931-1997, undated3
- Camperdown Mill49
- Carolina Bands Collection34
- Catherine M. McCottry, M.D. Papers10
- Cemeteries24
- Cemeteries 1
- Chamber of Commerce1
- Charles Cross Collection of Buchenwald Concentration Camp Photographs, 194518
- Charles Family Civil War Era Letters 2
- Charles Fraser Sketchbook, 1793-17961
- Charles Fraser's Sketchbook, 1796-1805115
- Charles Henry Meltzer Papers, 1839-19402
- Charles N. Bayless Photos of Charleston and Georgetown County, S.C.1,613
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19953
- Charleston Earthquake 1886148