- Greer Textiles51
- Gregg-Graniteville Photographic Archive136
- Grimke family papers, 1678-197716
- Harbison Agricultural College Photograph Collection113
- Harby, Moise, Levy, Moses, Davis Family Photographs55
- Harry Blas and Erika Stockfleth Blas Papers, circa 1910-circa 198020
- Harry and William Birch Collection961
- Helen Evangeline Banks Harrison papers (circa 1850 - 1985)1
- Henry Orion Nichols Collection5,171
- Henry Orion Nichols Collection 582
- Henry William Ravenel Papers, 1739-19351
- Heritage Green33
- Historic Southern Naturalists1
- Historical and Governing Records, 1841-19253
- History of the University of South Carolina School of Medicine - Columbia409
- Horace Gilbert Smithy, Jr., M.D. Papers112
- Illustrated Newspaper Clippings, 1840-191737
- Images from the Records of the Charleston County Public Library181
- Isaiah Bennett Papers, ca. 1932-20022
- J. Arthur Brown Papers, 1937 - 198858