- Drayton Family Papers, 1837-186946
- Horace Gilbert Smithy, Jr., M.D. Papers40
- City Year Books for Charleston, South Carolina, 1880-195135
- Kahal Kadosh Beth Elohim Congregation Records33
- Charleston Dental Association Records30
- Laura Bragg Papers25
- Slave Records in the Discrete Manuscript Collection25
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24
- William Ancrum Letter Book and Account Book22
- Historical and Governing Records, 1841-192521
- Allston Family Papers, 1730-190118
- Buildings and Properties, 1841-193718
- Mary Lamboll Thomas Beach Papers, 1822-189018
- Rabbi Jacob S. Raisin Papers18
- Charleston Firefighters Rosters, 1862-186416
- Cranston Family Papers, 1822-195916
- Henry William Ravenel Papers, 1739-193516
- Septima P. Clark Papers, ca. 1910-ca. 199016
- Cleveland L. Sellers, Jr. Papers, 1934 - 200315
- Bacot Family Papers, 1752-197314