- Charleston Dental Association Records30
- Charleston Firefighters Rosters, 1862-186416
- Charleston Iron Works records, 19072
- Charleston Museum Collection1
- Charleston Museum Collection of Revolutionary War Letters70
- Charleston Slave Passes3
- Charleston and Savannah Railroad Records1
- Circular letter, 1783 April 2 – From Guerard, Benjamin1
- City Year Books for Charleston, South Carolina, 1880-195135
- Civic Services Committee Papers1,121
- Cleveland L. Sellers, Jr. Papers, 1934 - 200315
- College of Charleston Magazines48
- Cora Godfrey Justice Family Papers, 1816-19871
- Craft and Crum Families, 1780-200711
- Cranston Family Papers, 1822-195916
- Daily reports, 1863 Dec. 17-237
- Drayton Family Papers, 1837-186946
- Drayton Papers, 1701-20047
- Drayton family papers, 1837-18691
- Eighteenth & Nineteenth Century Correspondence Collection4