- Loose Papers of the Summerville Museum and Research Center7
- Lucas-Porcher Family Papers, 1827-197220
- Lutheran Church Records of South Carolina65
- Lutheran Theological Southern Seminary Collection10
- Lydia Jane Waring Estate Book, 1840-18471
- Lynch Family Letters, 1858-1866447
- MUSC College of Dental Medicine Oral History Project, 20119
- Malloy Family Papers, 1861-190770
- Mamie E. Garvin Fields Papers, 1894 - 198730
- Manigault Family Papers, 1685-19711
- Marguerite Andell Collection, 1919-194610
- Martha Elizabeth Cunningham Monteith Collection3
- Martha Puckmire letters of guardianship and apprentices' indenture, 18522
- Marx E. Cohen Plantation Records, 1840-18683
- Mary Lamboll Thomas Beach Papers, 1822-189018
- Mary Motte Alston Pringle Receipt Book155
- Materials towards a history of the Baptists in the provinces of Maryland, Virginia, North Carolina, South Carolina, Georgia1
- Mathurin Guerin Gibbs Plantation Register, 1824-18751
- Matthew J. & Arlyn Bruccoli Collection of F. Scott Fitzgerald1
- Maxcy Gregg Papers, 1835-1888.7