- Rabbi Jacob S. Raisin Papers109
- Ragsdale Family Papers, 1844-ca.192010
- Ravenel Family Papers, 1695-19258
- Records of Charleston fire companies, 1862-18647
- Records of the Bricklayers, Masons and Plasterers International Union of America, 1950-19558
- Records of the Church of the Holy Cross, 1788-19428
- Reverend Alexander Glennie Meteorological Observations, 1834-18808
- Richard L. Johnson Medical Record Book, 1863-1864, 1867-18831
- Richard L. Walker: In His Own Words2
- Richmond Plantation Journal, 1859-18601
- Robert B. Ariail Collection of Historical Astronomy1
- Robert F. W. Allston papers, 1817-18681
- Robert Gilmor Travel Account1
- Robert Heriot Correspondence, 17812
- Roper Hospital Digital Collections1
- Rose Hill Plantation Time Books, 18783
- Rose P. Ravenel Family Papers, 1857-ca. 1920.1
- Roslin Plantation Journal, 1813-18151
- Roswell T. Logan Journal, 1852-18651
- Samuel Badger Papers, 1767-177314