- Fritz Hollings: In His Own Words1
- Gaillard Family Papers, 1758-19011
- Gaillard Family Papers, 1795-18501
- General Orders of William Moultrie and Benjamin Lincoln, 17791
- George Chicken Journal, 1715-17161
- Glenn Drayton journal, 1814-18641
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Gourdin Family Collection, 1707-19031
- Harby Academy Cashbook1
- Hebrew Benevolent Society Papers1
- Henry Laurens Account Book, 1766-17331
- Henry Mouzon Plat Book, 1769-18191
- Henry William Ravenel's Private Journals1
- History of the Charleston Fire Department, 19531
- History of the University of South Carolina School of Medicine - Columbia1
- Holloway Family Collection1
- Huger Family Papers, 1795-18971
- Hunger in America1
- Invoice of rice sales for Anthony Clarkson, 1762 Oct. 301
- Irish Volunteers Company records, 1798-19291