- Samuel Lander Papers41
- Samuel Miller apprenticeship indenture, 18051
- Samuel Pope, Seaman's Protection Certificate, 18201
- Sandy Island Plantation Journals/Almanacs, 1792-17984
- Sanitary Survey of the Rural Portion of Charleston County, 19211
- Sarah Campbell Allan, M.D. Papers 1895-19525
- Sarah Campbell Allan, M.D. Papers 1895-19531
- Senator Burnet R. Maybank Papers, 1914-19733
- Septima P. Clark Papers, ca. 1910-ca. 199098
- Slave Records in the Discrete Manuscript Collection86
- Slavery at South Carolina College, 1801-186516
- Small-Whaley Family Papers, 1796-19941
- South Carolina Dental Association Records14
- South Carolina Historical Records Survey Collection1,083
- South Carolina Historical Society Manuscripts10
- South Carolina Library Association Digital Collection2
- South Carolina Medical Association Oral History Collection1
- South Carolina Public Library History, 1930 - 194548
- South Carolina and the Civil War239
- South Caroliniana Library Map Collection3