- Sporting Journal of Maxcy Gregg2
- Springfield Plantation Journal,1831 - 18641
- St. Andrew's Society of Charleston Records, 1729-2001118
- St. Paul's Episcopal Church records, 1819-1971134
- Stokes Grocery Store Ledger412
- Stoney Family Papers, 1775-19492
- Strom Thurmond Collection, Mss 1001,154
- Susan M.L. Wales Journal, 1887-18951
- Susan Pringle Alston’s Receipts, 1891-192120
- Temple Sinai (Sumter, S.C.) Records3
- The American Revolution in South Carolina1,501
- The Black Whale, by Gabriel E. Manigault1
- The Calvin Shedd Papers, 1862 - 186443
- The Church Register of the Salem Methodist Episcopal Church, South.1
- The Citadel Alumni War Veterans Collection2
- The Citadel and the American Civil War10
- The Development of the Printed Page: 150 Examples of Handpress Printing and its Antecedents, ca. 1200 to 193719
- The Fundamental Constitutions of Carolina, 16691
- The James Poyas Daybook1
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera229