- University of South Carolina Student Exams, 1854 - 191743
- Barnwell Family Papers41
- South Carolina and the Civil War41
- Henry Laurens papers, 1747-186040
- Colin J. McRae Papers, Huse Audit Series35
- Edmondston-Alston Family Letters and Paper Materials, 1782-191935
- Neves Family Letters29
- Fairfield County Manuscript Collection28
- Horace Gilbert Smithy, Jr., M.D. Papers27
- Inventory of S.C. Church Archives27
- John H. McCray papers, 1929-198926
- John C. Calhoun Letters, 1824-185025
- Slave Records in the Discrete Manuscript Collection25
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)23
- William Drayton Rutherford Papers22
- Drayton Family Papers, 1837-186921
- Charleston Museum Collection of Revolutionary War Letters18
- Heyward and Ferguson Family Papers, 1806-192318
- Family Bible Records17