- Anna D. Kelly Papers, 1930s - 19992
- Edwin Hughes Collection2
- Family Bible Records2
- Flagg Family Papers, 1832-19262
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera2
- William Drayton Rutherford Papers2
- Armstrong Family Papers, 1900-19301
- Bacot Family Papers, 1752-19731
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- J. Arthur Brown Papers, 1937 - 19881
- James W. Colbert, Jr., MD, Oral History Project, 20091
- John Henry McCray papers, 1929-19891
- John Shaw Billings Scrapbook1
- Journal of Robert Barnwell Plantations, 1838-18591
- Lutheran Theological Southern Seminary Collection1
- Modjeska Simkins Papers, 1909-19921
- Ravenel Family Papers, 1695-19251
- Samuel Lander Papers1
- Strom Thurmond Collection, Mss 1001
- Warren Hubert Moise Letters, 1933-19391