- Grimke family papers, 1678-19775
- Hurricane Hugo Oral History Collection, 20095
- Wilkinson-Keith Family Papers5
- Fairfield County Manuscript Collection4
- Berkeley County (S.C.) Memories3
- James Kershaw Papers, 1786-18253
- Marx E. Cohen Plantation Records, 1840-18683
- Paul Hamilton Papers3
- Trowbridge Family Papers3
- Collected Civil War Papers of Colonel Benjamin Franklin Eshleman2
- Francis Peyre Porcher Papers2
- Historical and Governing Records, 1841-19252
- Kahal Kadosh Beth Elohim Congregation Records2
- Langdon Cheves Papers, 1777-18642
- Laura Bragg Papers2
- MUSC College of Dental Medicine Oral History Project, 20112
- Malloy Family Papers, 1861-19072
- Reverend Alexander Glennie Meteorological Observations, 1834-18802
- South Carolina Historical Records Survey Collection2
- Thomas J. Tobias papers, ca. 1790-19702