- Papers of the Cox and Chesnut Families, 1792-185836
- Civic Services Committee Papers35
- University of South Carolina Student Exams, 1854 - 191735
- Grimke family papers, 1678-197734
- James Glen Papers32
- Neves Family Letters30
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera30
- Inventory of S.C. Church Archives25
- WPA Federal Writers' Project on African American Life in South Carolina24
- Slave Records in the Discrete Manuscript Collection23
- Charleston Museum Collection of Revolutionary War Letters21
- Family Bible Records20
- John Shaw Billings Scrapbook18
- Strom Thurmond Collection, Mss 10018
- Edwin Hughes Collection17
- Gooch Family Papers, 1754-194717
- Langdon Cheves Papers, 1777-186417
- Malloy Family Papers, 1861-190716
- Samuel Lander Papers15
- St. Paul's Episcopal Church records, 1819-197115