- College of Charleston Magazines48
- Drayton Family Papers, 1837-186946
- Horace Gilbert Smithy, Jr., M.D. Papers40
- City Year Books for Charleston, South Carolina, 1880-195135
- Kahal Kadosh Beth Elohim Congregation Records33
- Charleston Dental Association Records30
- Henry William Ravenel Papers, 1739-193530
- Laura Bragg Papers25
- Slave Records in the Discrete Manuscript Collection25
- John F. Riley papers, 1884-1921 (bulk 1884-1895)24
- William Ancrum Letter Book and Account Book24
- Henry William Ravenel, Plants and Planter22
- Historic Southern Naturalists22
- Allston Family Papers, 1730-190121
- Historical and Governing Records, 1841-192521
- Papers of the Cox and Chesnut Families, 1792-185821
- Rabbi Jacob S. Raisin Papers21
- Mamie E. Garvin Fields Papers, 1894 - 198720
- Septima P. Clark Papers, ca. 1910-ca. 199019
- William Drayton Rutherford Papers19