- Family Bible Records96
- Historic Southern Naturalists95
- Medical Society of South Carolina Digital Collections80
- Armstrong Family Papers, 1900-193071
- John Shaw Billings Scrapbook71
- Lutheran Church Records of South Carolina65
- Francis Peyre Porcher Papers62
- William Tennent III Journal and Album62
- Henry William Ravenel, Plants and Planter61
- Isaiah Bennett Papers, ca. 1932-200257
- Bonds Conway Papers, 1763-190755
- Grimke family papers, 1678-197749
- South Carolina Public Library History, 1930 - 194548
- Collected Receipts of William Butler of Greenville46
- Thomas J. Tobias papers, ca. 1790-197044
- 'John Henry McCray papers, 1929-1989'43
- The Calvin Shedd Papers, 1862 - 186443
- Berkeley County (S.C.) Memories39
- City Year Books for Charleston, South Carolina, 1880-195135
- Carolina Bands Collection34