- Brandon Mill Ledger1
- Buildings and Properties, 1841-193718
- Captain William Boykin Lyles Estate Record Ledger1
- Carolina Bands Collection34
- Catalog of the Collections of Minerals in the College of South Carolina2
- Catherine M. McCottry, M.D. Papers1
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser Book of Precedents, 1800-18191
- Charles Henry Meltzer Papers, 1839-194010
- Charleston Bible Society Records, 1815-20101
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-1995190
- Charleston City Directories2
- Charleston Dental Association Records30
- Charleston Firefighters Rosters, 1862-186416
- Charleston Iron Works records, 19072
- Charleston Museum Collection1
- Charleston Museum Collection of Revolutionary War Letters70
- Charleston Slave Passes3
- Charleston and Savannah Railroad Records1
- Chesnut Family Papers, 1741-19004