- Bernice Robinson Papers, 1920-1989111
- Berry Family Papers, 1767-19291
- Board of Trustees Annual Reports91
- Bonds Conway Papers, 1763-190755
- Book Lovers' Club, 1927 - 196917
- Books and Pamphlets9
- Bowman Family Papers, 1835-18924
- Brandon Mill Ledger280
- Buildings and Properties, 1841-193718
- Captain William Boykin Lyles Estate Record Ledger1
- Carolina Bands Collection34
- Catalog of the Collections of Minerals in the College of South Carolina2
- Catherine M. McCottry, M.D. Papers1
- Certificate of citizenship, 1871 - McCormick, John, fl. 18711
- Charles Fraser Book of Precedents, 1800-18191
- Charles Henry Meltzer Papers, 1839-194010
- Charleston Bible Society Records, 1815-20101
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-1995190
- Charleston City Directories2
- Charleston Dental Association Records30