- Lynch Family Letters, 1858-18667
- St. Paul's Episcopal Church records, 1819-19717
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)6
- Charleston Branch of the National Association for the Advancement of Colored People Papers, 1920-19955
- Colin J. McRae Papers, Huse Audit Series5
- G. Ross Roy Collection of Burnsiana and Scottish Literature5
- James W. Colbert, Jr., MD, Oral History Project, 20095
- Paul Hamilton Papers5
- Slavery at South Carolina College, 1801-18655
- Edwin Hughes Collection4
- J. Marion Sims Letters4
- James Kershaw papers, 1786-18254
- Slave Records in the Discrete Manuscript Collection4
- The Marian Bruce Logan Collection of Civil Rights Activism, Personal Correspondence, 1945-19894
- American Revolution Records in the Discrete Manuscript Collection3
- Collected Papers of the Holland Family of Greenville County3
- Flagg Family Papers, 1832-19263
- Gabriel Manigault Journal, 1774-17843
- John R. Beaty Letters3
- South Carolina Historical Society Manuscripts3