- Flagg Family Papers, 1832-192617
- John R. Beaty Letters17
- Langdon Cheves Papers, 1777-186417
- 2nd South Carolina Regiment Paybook, 177516
- Allston Family Papers, 1730-190116
- Gooch Family Papers, 1754-194716
- Mills Family of Greenville16
- Stokes Grocery Store Ledger16
- The Joel Myerson Collection of Nineteenth-Century American Manuscripts, Images, and Ephemera16
- WPA Federal Writers' Project on African American Life in South Carolina16
- McBee Sons & Company Store Ledger Book, 1846-186114
- St. Andrew's Society of Charleston Records, 1729-200114
- Edwin Hughes Collection12
- John West: In His Own Words12
- Buildings and Properties, 1841-193710
- Mary Motte Alston Pringle Receipt Book10
- Architect - George E. Walker9
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections9
- John C. Calhoun Papers, 1782-18509
- MUSC College of Dental Medicine Oral History Project, 20119