- Agatha Aimar Simmons Papers, 1903-19621
- American Revolution Records in the Discrete Manuscript Collection1
- Anna E. Alston Albums, 1880-19211
- Anne Simons Deas papers, ca. 1900.1
- Charleston Museum Collection of Revolutionary War Letters1
- Clemson University Class of 19391
- Colin J. McRae Papers, Huse Audit Series1
- Gabriel Manigault Journal, 1774-17841
- Gertrude Sanford Legendre Papers, 1844-19961
- Glover Family Papers, 1729-ca.19551
- Gooch Family Papers, 1754-19471
- Good Hope Plantation Journal, 1835-1874 (bulk 1835-1857)1
- Grimke family papers, 1678-19771
- Historic Southern Naturalists1
- Inventory of S.C. Church Archives1
- Isaiah Bennett Papers, ca. 1932-20021
- John Shaw Billings Scrapbook1
- John West: In His Own Words1
- Laura Bragg Papers1
- Lucas-Porcher Family Papers, 1827-19721