- Chester County Historical Collection, 1739-19971
- Circular Congregational Church Records, 1732-1796 (bulk 1800-1910s)1
- City of Charleston Collection1
- Family Bible Records1
- Friendly Moralist Society Records, 1841-18561
- Gabriel Manigault Journal, 1774-17841
- Halley's Comet Project, 1985-19861
- Historic Southern Naturalists1
- James Glen Papers1
- John Shaw Billings Scrapbook1
- Loose Papers of the Summerville Museum and Research Center1
- Lynch Family Letters, 1858-18661
- Mamie E. Garvin Fields Papers, 1894 - 19871
- Mary Lamboll Thomas Beach Papers, 1822-18901
- Mathurin Guerin Gibbs Plantation Register, 1824-18751
- Modjeska Simkins Papers, 1909-19921
- Philip Simmons Collection1
- Phillis Wheatley Literary and Social Club Papers1
- Ragsdale Family Papers, 1844-ca.19201
- Slavery at South Carolina College, 1801-18651