- Langdon Cheves Papers, 1777-18646
- Slave Records in the Discrete Manuscript Collection6
- University of South Carolina Student Exams, 1854 - 19176
- Collected Receipts of William Butler of Greenville5
- Cleveland L. Sellers, Jr. Papers, 1934 - 20034
- Colin J. McRae Papers, Huse Audit Series4
- Francis Peyre Porcher Papers4
- Grimke family papers, 1678-19774
- John Henry McCray papers, 1929-19894
- Kahal Kadosh Beth Elohim Congregation Records4
- Lazarus and Hirsch Family Papers4
- South Carolina Public Library History, 1930 - 19454
- W.P.A. Inventories of Church Archives in South Carolina, 1937-19394
- Wilkinson-Keith Family Papers4
- Architect - George E. Walker3
- Bacot Family Papers, 1752-19733
- Charleston Museum Collection of Revolutionary War Letters3
- Henry William Ravenel, Plants and Planter3
- James Glen Papers3
- Lutheran Church Records of South Carolina3