- Eugene Avery Adams papers, 1892-196897
- Family Bible Records96
- Historic Southern Naturalists96
- Board of Trustees Annual Reports91
- Slave Records in the Discrete Manuscript Collection89
- Halley's Comet Project, 1985-198688
- Fairfield County Manuscript Collection87
- In Camp And At The Front, WW1 Selections, South Carolina Political Collections82
- Medical Society of South Carolina Digital Collections80
- Flagg Family Papers, 1832-192674
- Armstrong Family Papers, 1900-193071
- John Shaw Billings Scrapbook71
- WWII Letters to Evelyn Dill71
- Charleston Museum Collection of Revolutionary War Letters70
- Malloy Family Papers, 1861-190770
- Francis Peyre Porcher Papers69
- Cleveland L. Sellers, Jr. Papers, 1934 - 200366
- Neves Family Letters66
- Drayton Family Papers, 1837-186965
- Lutheran Church Records of South Carolina65