- St. Paul's Episcopal Church records, 1819-19719
- John Henry McCray Papers, 1929-19897
- American Revolution Records in the Discrete Manuscript Collection6
- Ball Family Papers, 1631-18966
- Gabriel Manigault Journal, 1774-17846
- Henry William Ravenel Papers, 1739-19356
- Wilkinson-Keith Family Papers6
- Armstrong Family Papers, 1900-19305
- Berkeley County (S.C.) Memories5
- Collected Papers of the Holland Family of Greenville County5
- G. Ross Roy Collection of Burnsiana and Scottish Literature5
- Isaiah Bennett Papers, ca. 1932-20025
- Malloy Family Papers, 1861-19075
- Coffin Point Plantation Journals, 1800-18164
- Maxcy Gregg Papers, 1835-1888.4
- Walter Pantovic Slavery and African American History Collection4
- Cleveland L. Sellers, Jr. Papers, 1934 - 20033
- Eighteenth & Nineteenth Century Correspondence Collection3
- Glover Family Papers, 1729-ca.19553
- Halley's Comet Project, 1985-19863