- Colin J. McRae Papers, Huse Audit Series536
- Collected Civil War Papers of Colonel Benjamin Franklin Eshleman28
- Collected Papers of the Holland Family of Greenville County56
- Collected Receipts of William Butler of Greenville46
- Collection of Bishop Patrick Lynch Confederate Commissioner Papers, 1864-186510
- College of Charleston Board of Trustees Minutes52
- College of Charleston Magazines48
- Colleton County Memorial Library Bookmobile History3
- Colleton County Memorial Library Minute Books and Ledgers1
- Confederate Military Correspondence3
- Congarees Store Account Book1
- Continental Army Southern Department Records, 1778-1890 (Bulk 1778-1780)387
- Cora Godfrey Justice Family Papers, 1816-19872
- Cote Bas and Mepkin Plantations Journals, 1865-18774
- Craft and Crum Families, 1780-200711
- Cranston Family Papers, 1822-195916
- Daily reports, 1863 Dec. 17-237
- DeBerniere Family Papers, 1790-1930 (bulk 1790-1860)1
- Deas Family Papers and Research, 1766-19762
- Delbert Claire Brandt Collection3